Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Alb-MYLIP*)1Pton
Name:	transgene insertion 1, Peter Tontonoz
MGI ID:	MGI:5706928
Synonyms:	L-sIDOL
Transgene:	Tg(Alb-MYLIP*)1Pton  Location: unknown
Alliance:	Tg(Alb-MYLIP*)1Pton page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Nucleotide substitutions   Tg(Alb-MYLIP*)1Pton expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MYLIP (29116) Mylip  (MGI:2388271)   Mutation details: A degradation-resistant, dominant-active form of human MYLIP/IDOL carrying K293R, K309R, K310R, and K320R mutations is expressed under the direction of the mouse albumin enhancer/promoter and followed by bovine growth hormone polyA. (J:228420)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:228420 Calkin AC, et al., Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circ Res. 2014 Aug 1;115(4):442-9
All:	2 reference(s)