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Gene Expression Data
Assay Details
Assay
Reference: J:93157 Duarte A, et al., Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004 Oct 15;18(20):2474-8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5706822
Gene symbol: Dll4
Gene name: delta like canonical Notch ligand 4
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 8.0; Dll4tm1Jrt/Dll4+ (more )
Note: Two-somite stage.
Structure Level Pattern Image Note
TS12: cardiogenic plate Present 2A
TS12: dorsal aorta Present 2A

Specimen 2B: embryonic day 8.5; Dll4tm1Jrt/Dll4+ (more )
Note: Five- to ten-somite stage
Structure Level Pattern Image Note
TS13: dorsal aorta Present 2B
TS13: internal carotid artery Present 2B
TS13: umbilical artery Present 2B
TS13: vitelline artery Present 2B
TS13: heart Present Regionally restricted 2B Expression was in the endothelial lining.
TS13: arterial system Present Regionally restricted 2B Expression was detected in the branchial arch arteries.
TS13: yolk sac Present Regionally restricted 2B Expression was detected in the posterior region of the yolk sac where the arteries are formed.

Specimen 2C: embryonic day 8.5; Dll4tm1Jrt/Dll4+ (more )
Note: Five- to ten-somite stage
Structure Level Pattern Image Note
TS13: dorsal aorta Present 2C
TS13: internal carotid artery Present 2C
TS13: umbilical artery Present 2C
TS13: vitelline artery Present 2C
TS13: heart Present Regionally restricted 2C Expression was in the endothelial lining.
TS13: arterial system Present Regionally restricted 2C Expression was detected in the branchial arch arteries.
TS13: yolk sac Present Regionally restricted 2C Expression was detected in the posterior region of the yolk sac where the arteries are formed.

Specimen 2E: embryonic day 10.5; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS17: arterial system Present 2E

Specimen 2F: embryonic day 10.5; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS17: arterial system Present 2F

Specimen 2G: embryonic day 9.5; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS15: umbilical artery Present 2G

Specimen 2H: embryonic day 9.5; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS15: umbilical artery Present 2H

Specimen 3C: embryonic day 9.0; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS14: vitelline artery Present 3C

Specimen 3D: embryonic day 9.0; Dll4tm1Jrt/Dll4tm1Jrt (more )
Structure Level Pattern Image Note
TS14: yolk sac blood vessel Present 3D In mutant embryos the expression is observed throughout the yolk sac vessels.

Specimen 3E: embryonic day 9.0; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS14: intersomitic artery Present 3E

Specimen 3F: embryonic day 9.0; Dll4tm1Jrt/Dll4tm1Jrt (more )
Structure Level Pattern Image Note
TS14: intersomitic artery Present 3F There was an abnormal accumulation of lacZ-positive cells in the apical portion of the intersomitic vessels.

Specimen 3G: embryonic day 9.0; Dll4tm1Jrt/Dll4+ (more )
Structure Level Pattern Image Note
TS14: intersomitic artery Present 3G

Specimen 3H: embryonic day 9.0; Dll4tm1Jrt/Dll4tm1Jrt (more )
Structure Level Pattern Image Note
TS14: intersomitic artery Present 3H There was an abnormal accumulation of lacZ-positive cells in the apical portion of the intersomitic vessels.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory