Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(hs599-cre/ERT2,-GFP)119Jlr
Name:	transgene insertion 119, John Rubenstein
MGI ID:	MGI:5705409
Synonyms:	599-CreER-IRES-GFP
Transgene:	Tg(hs599-cre/ERT2,-GFP)119Jlr  Location: unknown
Alliance:	Tg(hs599-cre/ERT2,-GFP)119Jlr page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Tg(hs599-cre/ERT2,-GFP)119Jlr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note human hs599   Mutation details: This transgene contains the human enhancer element hs599, which is flanked on human Chr 15 by the microRNA 8063 (MIR8063) and transmembrane and coiled-coil domains 5A (TMCO5A) loci, followed by a minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:94077)

Activity:	Tissue activity of this recombinase allele
Driver:	hs599 (human) Summary of all recombinase alleles driven by hs599.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:	3 reference(s)