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Gene Expression Data
Assay Details
Assay
Reference: J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5701412
Gene symbol: Sox17
Gene name: SRY (sex determining region Y)-box 17
Antibody: anti-Sox17 (AF1924)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 4A Control: embryonic day 7.5 (more )
Note: late bud stage
Structure Level Pattern Image Note
TS11: definitive endoderm Present 4A Control
Specimen 4A Mutant: embryonic day 7.5; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant. late bud stage
Structure Level Pattern Image Note
TS11: definitive endoderm Present 4A Lhx1 delta Epi Unlike in wild type, endodermal cells obscure the node.
Specimen 4B Control: embryonic day 7.5 (more )
Note: early headfold stage; double labeled: red - Sox17; white - F-actin.
Structure Level Pattern Image Note
TS11: definitive endoderm Present 4B Control
Specimen 4B Mutant: embryonic day 7.5; Lhx1tm1Bhr/Lhx1tm2.1Rob, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant. early headfold stage; double labeled: red - Sox17; white - F-actin.
Structure Level Pattern Image Note
TS11: definitive endoderm Present 4B Lhx1 delta Epi Unlike in wild type, the node is encapsulated by endodermal cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory