Pvalbtm2(cre/ERT2)Zjh
Targeted Allele Detail
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Symbol: |
Pvalbtm2(cre/ERT2)Zjh |
Name: |
parvalbumin; targeted mutation 2, Z Josh Huang |
MGI ID: |
MGI:5700403 |
Synonyms: |
PV-2A-CreEr, PV-CreER |
Gene: |
Pvalb Location: Chr15:78075314-78090600 bp, - strand Genetic Position: Chr15, 36.93 cM, cytoband E
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Alliance: |
Pvalbtm2(cre/ERT2)Zjh page
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Pvalbtm2(cre/ERT2)Zjh expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Pvalb (MGI:97821) |
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Mutation details: A targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), followed by a frt-flanked neo cassette, upstream of the stop codon.
(J:235123)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pvalb
(mouse)
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User Notes:
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Additional information submitted by the research community
Additional information submitted by the research community
The donating investigator reports that this strain is superior to Pvalbtm1(cre/ERT2)Zjh (Stock No. 010777) in which CreERT2 is inserted into the initiation codon of the Pvalb gene, creating a knockin/knockout allele.
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:235123 He M, et al., Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21;91(6):1228-1243 |
All: |
3 reference(s) |
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