Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Viptm2.1(flpo)Zjh
Name:	vasoactive intestinal polypeptide; targeted mutation 2.1, Z Josh Huang
MGI ID:	MGI:5700390
Synonyms:	VIP-Flp, VIP-ires-Flpo
Gene:	Vip  Location: Chr10:5589218-5597617 bp, + strand  Genetic Position: Chr10, 1.97 cM, cytoband A1
Alliance:	Viptm2.1(flpo)Zjh page

Germline Transmission:	Earliest citation of germline transmission: J:235123
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Viptm2.1(flpo)Zjh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Vip (MGI:98933)   Mutation details: The targeting vector is designed to insert an internal ribosome entry site (IRES) fused to flpo recombinase gene (a codon-optimized flpe gene modified for translation in mammalian cells and higher recombination efficiency in cells and in mice), followed by a loxP-flanked neo cassette, downstream of the stop codon of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:235123)

Activity:	Tissue activity of this recombinase allele
Driver:	Vip (mouse) Summary of all recombinase alleles driven by Vip. Alliance mouse Vip gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vip Mutation:	22 strains or lines available

Original:	J:235123 He M, et al., Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21;91(6):1228-1243
All:	12 reference(s)