Alktm1Dgen
Targeted Allele Detail
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|
| Symbol: |
Alktm1Dgen |
| Name: |
anaplastic lymphoma kinase; targeted mutation 1, Deltagen |
| MGI ID: |
MGI:5700373 |
| Gene: |
Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
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| Alliance: |
Alktm1Dgen page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:226526
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence from exon 22, containing 35bp coding for the protein, was replaced by a IRES-beta-gal-neomycin selection cassette. This mutation is predicted to lead to premature transcript termination and deletion of the transmembrane and kinase domains in the encoded protein.
(J:226526)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Alk Mutation: |
64 strains or lines available
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|
| Original: |
J:226526 Bilsland JG, et al., Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology. 2008 Feb;33(3):685-700 |
| All: |
2 reference(s) |
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Analysis Tools
