Arf6<tm2.1Yaka> Targeted Allele Detail MGI Mouse (MGI:5698618)

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Arf6^tm2.1Yaka
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Summary

Symbol:	Arf6^tm2.1Yaka
Name:	ADP-ribosylation factor 6; targeted mutation 2.1, Yasunori Kanaho
MGI ID:	MGI:5698618
Synonyms:	Arf6^flox
Gene:	Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
Alliance:	Arf6^tm2.1Yaka page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:224921
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Conditional ready)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exons 1 and 2 floxed. (J:224921)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Arf6 Mutation:	10 strains or lines available

References

Original:	J:224921 Hongu T, et al., Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial beta1 integrin recycling. Nat Commun. 2015;6:7925
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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