Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Lhx1tm1.1(icre)Rob
Name:	LIM homeobox protein 1; targeted mutation 1.1, Elizabeth J Robertson
MGI ID:	MGI:5698524
Synonyms:	Lhx1iCreIRESLacZ, Lhx1iCre-LacZ, Lhx1iCre-nLacZ, Lhx1iCrenLacZ
Gene:	Lhx1  Location: Chr11:84409110-84416361 bp, - strand  Genetic Position: Chr11, 51.31 cM
Alliance:	Lhx1tm1.1(icre)Rob page

Germline Transmission:	Earliest citation of germline transmission: J:226614
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Lhx1tm1.1(icre)Rob expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lhx1 (MGI:99783)   Mutation details: The targeting construct inserted in frame with exon 1 an improved cre recombinase gene (icre), IRES, nuclear lacz reporter gene and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the recombinase gene. (J:226614)

Activity:	Tissue activity of this recombinase allele
Driver:	Lhx1 (mouse) Summary of all recombinase alleles driven by Lhx1. Comparative matrix view of recombinase activities Alliance mouse Lhx1 gene page

In Mice Carrying this Mutation:

36 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx1 Mutation:	22 strains or lines available

Original:	J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
All:	1 reference(s)