About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5698424
Gene symbol: Prkaa2
Gene name: protein kinase, AMP-activated, alpha 2 catalytic subunit
Results
Specimen 2E: postnatal day 23 (more )
Structure Level Pattern Image Note
TS28: hippocampus Present Regionally restricted 2E Expression in neuropil and pyramidal cell nuclei, and cells of oligodendrocyte and astrocyte morphology.
TS28: corpus callosum Present Regionally restricted 2E Expression in a small number of astrocytes in white matter tracts.

Specimen 3C: postnatal day 30 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present Regionally restricted 3C Expression in Purkinje cells and stellate cells of the molecular layer.
TS28: cerebellum molecular layer Present Regionally restricted 3C Expression in Purkinje cells and stellate cells of the molecular layer.
TS28: cerebellum granule cell layer Weak Regionally restricted 3C Lower levels of expression in cerebellar granule cells.
TS28: cerebellum white matter Present Scattered 3C Expression in scattered cells.
TS28: inferior colliculus Present Regionally restricted 3C Expression in neurons in the inferior colliculus.

Specimen 4C: postnatal day 12 (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Strong Regionally restricted 4C High expression in nucleus of all neurons.
TS28: main olfactory bulb glomerular layer Weak Regionally restricted 4C Lower expression in glomeruli.
TS28: main olfactory bulb mitral cell layer Present Regionally restricted 4C Expression in olfactory bulb mitral cells.

Specimen 5B: postnatal day 23 (more )
Structure Level Pattern Image Note
TS28: spinal cord Present Regionally restricted 5B High nuclear expression in all neurons, and cytoplasmic expression in motor neurons and astrocytes.
TS28: spinal cord white matter Present Scattered 5B Expression in scattered cells; most were of astrocyte morphology, but some had characteristic location of oligodendrocytes.

Specimen Table 1: postnatal (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present Regionally restricted High expression in neurons. No expression in astrocytes.
TS28: hippocampus Strong Regionally restricted Very high expression in activated astrocytes. Not detectable to high expression in astrocytes.
TS28: hippocampus pyramidal cell layer Strong Regionally restricted High expression in pyramidal cells.
TS28: cerebellum Present Regionally restricted Not detectable to high expression in astrocytes.
TS28: cerebellum granule cell layer Present Regionally restricted Expression in granule cells.
TS28: cerebellum Purkinje cell layer Strong Regionally restricted High expression in Purkinje cells.
TS28: spinal cord Present Regionally restricted Expression in motor neurons. Not detectable to high expression in astrocytes.
TS28: facial nucleus Strong Regionally restricted High expression in motor neurons.
TS28: main olfactory bulb glomerular layer Strong Regionally restricted High expression in mitral, granule and periglomerular cells.
TS28: main olfactory bulb granule cell layer Strong Regionally restricted High expression in mitral, granule and periglomerular cells.
TS28: main olfactory bulb mitral cell layer Strong Regionally restricted High expression in mitral, granule and periglomerular cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/30/2024
MGI 6.23
The Jackson Laboratory