Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Prnp-CRYAB)Z104Dbo
Name:	transgene insertion Z104, David R Borchelt
MGI ID:	MGI:5697709
Synonyms:	Z104
Transgene:	Tg(Prnp-CRYAB)Z104Dbo  Location: unknown
Alliance:	Tg(Prnp-CRYAB)Z104Dbo page

Strain of Origin:

(C3H/HeJ x C57BL/6J)F2

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Prnp-CRYAB)Z104Dbo expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CRYAB (1410) Cryab  (MGI:88516)   Mutation details: The transgenic construct contains cDNA of human alpha B crystallin under the control of the mouse Prnp, prion protein, gene promoter. The 6 kb promoter consists of the first exon, the first intron, and the fused 2nd and 3rd exons. Expression of the transgene is observed in the forebrain, cerebellum, spinal cord and kidney. No evidence of expression was found in lung, spleen, testes or liver. (J:226527)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:226527 Xu G, et al., Substantially elevating the levels of alphaB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation. J Neurochem. 2015 May;133(3):452-64
All:	1 reference(s)