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PolgGt(VET25A)Hiir
Gene trapped Allele Detail
Summary
Symbol: PolgGt(VET25A)Hiir
Name: polymerase (DNA directed), gamma; gene trap VET25A, Takashi Hiiragi
MGI ID: MGI:5696388
Gene: Polg  Location: Chr7:79095979-79116110 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Alliance: PolgGt(VET25A)Hiir page
Mutation
origin
Strain of Origin:  (C57BL/6 x C3H)F2
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
 
Mutation detailsThe lentiviral gene trap vector sinLV-pRRL-K contains a gene trapping splice acceptor; stop codons in all three reading frames; an internal ribosomal entry site (IRES); the Venus reporter gene with a nuclear localization signal; a woodchuck hepatitis post-transcriptional regulatory element (WPRE); central poly-purine tract (cPPT); Rev-responsive element (RRE); and Rous sarcoma virus promoter (RSV) all flanked by a self-inactivating lentiviral long terminal (LTR) consisting of U5, R and truncated U3 element (delta U3). The gene trap vector inserted into the 5'UTR of exon 1. (J:224530)
Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:  57 strains or lines available
References
Original:  J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory