Tg(RP23-352G18)1Coppa
Transgene Detail
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| Symbol: |
Tg(RP23-352G18)1Coppa |
| Name: |
transgene insertion 1, Roberto Coppari |
| MGI ID: |
MGI:5696226 |
| Synonyms: |
Sirt6BAC |
| Transgene: |
Tg(RP23-352G18)1Coppa Location: unknown
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| Alliance: |
Tg(RP23-352G18)1Coppa page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(RP23-352G18)1Coppa expresses
7 genes
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Mutation details: The transgenic construct was made using C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-352G18 containing the entire sirtuin 6 locus (Sirt6) as well as 109 kbp of centromeric flanking sequences (including a portion of the Gna15 locus, several complete loci [Gna11, Aes, Tle2, Tle6, BC025920, Ankrd24] and predicted genes [Gm31878, Gm31936, Gm32024]) and 70 kbp of telomeric flanking sequences (including the predicted gene Gm10778). The RP23-352G18 BAC DNA was modified only by insertion of an ampicillin resistance cassette. Founder line 1 has a 2-4 fold greater expression of Sirt6 as compared to wild-type.
(J:229077)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:229077 Anderson JG, et al., Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab. 2015 Nov;4(11):846-56 |
| All: |
5 reference(s) |
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Analysis Tools
