Gene Expression Data
Assay Details
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Assay
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Reference:
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J:53289
Yang X, et al., Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999 Apr;126(8):1571-80
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:5695445
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Gene symbol:
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Pecam1
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Gene name:
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platelet/endothelial cell adhesion molecule 1
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Results
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Specimen
3E:
embryonic day 9.5
(more  )
Specimen
3E:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: blood vessel |
Present |
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3E
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Expression was detected in a well-organized network of blood vessels.
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Specimen
3F:
(close )
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Genetic Background:
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either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)
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Mutant Allele(s):
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Smad5tm1Cxd/Smad5tm1Cxd
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: blood vessel |
Present |
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3F
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The mutant lacked an organized vascular network.
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Specimen
3G:
embryonic day 9.5
(more )
Specimen
3G:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: yolk sac |
Present |
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3G
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Expression was detected in endothelial cells.
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Specimen
3H:
(close )
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Genetic Background:
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either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)
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Mutant Allele(s):
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Smad5tm1Cxd/Smad5tm1Cxd
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: yolk sac |
Present |
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3H
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Expression was detected in endothelial cells.
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Specimen
not shown wild type:
embryonic day 8.5
(more )
Specimen
not shown wild type:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 8.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS14: vascular plexus |
Present |
Regionally restricted |
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Expression was detected in the primitive vascular plexus in the developing brain.
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Specimen
not shown mutant:
(close )
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Genetic Background:
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either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)
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Mutant Allele(s):
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Smad5tm1Cxd/Smad5tm1Cxd
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Age:
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embryonic day 8.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS14: vascular plexus |
Present |
Regionally restricted |
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Expression was detected in the primitive vascular plexus in the developing brain of the mutant, which was indistinguishable from wild type.
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Specimen
7A:
embryonic day 9.5
(more )
Specimen
7A:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: vascular plexus |
Present |
Regionally restricted |
7A
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Expression was detected in the vascular network in the developing brain.
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Specimen
7B:
(close )
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Genetic Background:
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either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)
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Mutant Allele(s):
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Smad5tm1Cxd/Smad5tm1Cxd
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: vascular plexus |
Present |
Regionally restricted |
7B
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The mutant vascular network was simplified and abnormal compared to wild type.
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Specimen
7C:
embryonic day 9.5
(more )
Specimen
7C:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section from whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: blood vessel |
Present |
Regionally restricted |
7C
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Expression was detected in the blood vessels in the limb.
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Specimen
7D:
(close )
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Genetic Background:
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either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)
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Mutant Allele(s):
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Smad5tm1Cxd/Smad5tm1Cxd
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section from whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: blood vessel |
Present |
Regionally restricted |
7D
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Blood vessels were enlarged and misshapen in the mutant limb.
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