Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(NEFH-tTA)8Vle
Name:	transgene insertion 8, Virginia M-Y Lee
MGI ID:	MGI:5693898
Synonyms:	NEFH-tTA
Transgene:	Tg(NEFH-tTA)8Vle  Location: unknown  Genetic Position: Chr12, 1.0 cM
Alliance:	Tg(NEFH-tTA)8Vle page

Strain of Origin:

(C57BL/6J x C3H/HeJ)F1

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The construct consists of ~18 kbp of the human neurofilament heavy polypeptide promoter (NEFH; from BAC RP11-91J21) upstream of the tetracycline-regulated transactivator gene (tTA or "Tet-Off"), followed by a polyA signal. Founder line 8 has its highest tTA expression in developmental late stage of the cortex, cerebellum and hippocampus, with expression also observed in olfactory bulb and in the rest of the brain. (J:225639)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available

Original:	J:225639 Walker AK, et al., Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathol. 2015 Nov;130(5):643-60
All:	12 reference(s)