Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-DRD3)3-10Kndl
Name:	transgene insertion 3-10, Eric R Kandel
MGI ID:	MGI:5693547
Synonyms:	tetO-D3R
Transgene:	Tg(tetO-DRD3)3-10Kndl  Location: unknown
Alliance:	Tg(tetO-DRD3)3-10Kndl page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-DRD3)3-10Kndl expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human DRD3 (1814) Drd3  (MGI:94925)   Mutation details: The tetO promoter consisting of seven operator sequences of the E. coli Tn10 tetracycline resistance operon and a Cytomegalovirus (CMV) minimal promoter, drives expression of the human DRD3 (D3R) gene and hGHpA (2.1 kb of the human growth hormone gene harboring the hGH polyadenylation signal). (J:225565)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:225565 Simpson EH, et al., Selective overexpression of dopamine D3 receptors in the striatum disrupts motivation but not cognition. Biol Psychiatry. 2014 Nov 15;76(10):823-31
All:	1 reference(s)