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Gene Expression Data
Assay Details
Assay
Reference: J:116113 Geng X, et al., Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development. Gene Expr Patterns. 2007 Jan 2;7(3):252-257
Assay type: RNA in situ
MGI Accession ID: MGI:5693535
Gene symbol: Six3os1
Gene name: SIX homeobox 3, opposite strand 1
Probe: Six3OS3 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen not shown: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: future brain Absent No expression in the anterior neural ectoderm.
Specimen 2B: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: future prosencephalon neural fold Absent 2B No expression in the anterior neural ridge (or any other embryonic region).
Specimen 2C: embryonic day 8.5 (more )
Note: 12 somite stage
Structure Level Pattern Image Note
TS13: future prosencephalon Present Regionally restricted 2C Expression in the ventral forebrain.
TS13: eye Present 2C Expression in the optic vesicle.
Specimen 2D: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future forebrain Present Regionally restricted 2D Expression in the ventral forebrain.
TS15: eye Present 2D Expression in the optic vesicle.
Specimen 2E: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forebrain Present Regionally restricted 2E Expression in the ventral forebrain.
TS17: eye Present 2E Expression in the optic vesicle.
Specimen 3A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: ganglionic eminence Present 3A
TS22: tectum Present 3A
TS22: thalamus Present Regionally restricted 3A Expression in the ventral thalamus.
Specimen 3C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: telencephalon septum Present Regionally restricted 3C Expression restricted to the ventricular zone.
TS22: hypothalamus ventricular layer Present 3C
TS22: hypothalamus mantle layer Absent 3C
TS22: thalamus Present Regionally restricted 3C Expression in the ventral thalamus.
TS22: midbrain tegmentum Weak 3C
TS22: pituitary gland Present 3C
Specimen 3E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: midbrain tegmentum Absent 3E
TS26: tectum Present 3E
TS26: telencephalon septum Present 3E
TS26: thalamus Present Regionally restricted 3E Expression in the ventral thalamus.
Specimen 3G: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: midbrain tegmentum Absent 3G
TS26: ganglionic eminence Present 3G
TS26: thalamus Present Regionally restricted 3G Expression in the ventral thalamus.
TS26: hypothalamus Present 3G
TS26: pituitary gland Present 3G
Specimen 3I: embryonic day 12.5 (more )
Note: Double labeled: blue - Six3os1; brown - Six3 (assay MGI:5693570).
Structure Level Pattern Image Note
TS20: hypothalamus ventricular layer Present 3I
TS20: hypothalamus mantle layer Absent 3I
Specimen 4A: embryonic day 9.5 (more )
Note: frontal view
Structure Level Pattern Image Note
TS15: diencephalon floor plate Present Regionally restricted 4A Expression in the posterior diencephalon.
TS15: telencephalon Present Regionally restricted 4A Expression in the ventral forebrain.
TS15: optic vesicle Present 4A
Specimen 4B: embryonic day 9.5; Six3tm1Gco/Six3tm1Gco (more )
Note: frontal view; the telencephalon is missing in these mutants
Structure Level Pattern Image Note
TS15: diencephalon floor plate Present Regionally restricted 4B Expression in the posterior diencephalon, as in wild type.
Specimen 4E: embryonic day 14.5; Six3tm2Gco/Six3+, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. These mice are indistinguishable from wild type.
Structure Level Pattern Image Note
TS22: lens Present 4E
TS22: retina Present 4E
Specimen 4F: embryonic day 14.5; Six3tm2Gco/Six3tm2.1Gco, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lens Present 4F Expression is as in wild type.
TS22: retina Present 4F Expression is as in wild type.
Specimen 4G: embryonic day 14.5; Six3tm2Gco/Six3+, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: blue - Six3os1; brown - Six3 (assay MGI:5693570). These mice are indistinguishable from wild type.
Structure Level Pattern Image Note
TS22: lens Present 4G
TS22: retina Present 4G
Specimen 4H: embryonic day 14.5; Six3tm2Gco/Six3tm2.1Gco, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant. Double labeled: blue - Six3os1; brown - Six3 (assay MGI:5693570).
Structure Level Pattern Image Note
TS22: lens Present 4H Expression is as in wild type.
TS22: retina Present 4H Expression is as in wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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