Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-DRD2)2-5Kndl
Name:	transgene insertion 2-5, Eric R Kandel
MGI ID:	MGI:5693386
Transgene:	Tg(tetO-DRD2)2-5Kndl  Location: unknown
Alliance:	Tg(tetO-DRD2)2-5Kndl page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-DRD2)2-5Kndl expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human DRD2 (1813) Drd2  (MGI:94924)   Mutation details: The tetO promoter, consisting of seven operator sequences of the E. coli Tn10 tetracycline resistance operon and a Cytomegalovirus (CMV) minimal promoter, drives expression on the human DRD2 (D2R) gene and hGHpA (2.1 kb of the human growth hormone gene harboring the hGH polyadenylation signal). (J:106982)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:106982 Kellendonk C, et al., Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron. 2006 Feb 16;49(4):603-15
All:	10 reference(s)