Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Ins2-HBEGF)6832Ugfm
Name:	transgene insertion 6832, University of Geneva, Faculty of Medicine
MGI ID:	MGI:5559198
Synonyms:	RIP-DTR
Transgene:	Tg(Ins2-HBEGF)6832Ugfm  Location: unknown
Alliance:	Tg(Ins2-HBEGF)6832Ugfm page

Strain of Origin:

C57BL/6 x CBA

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Ins2-HBEGF)6832Ugfm expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070)   Tg(Ins2-HBEGF)6832Ugfm expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Ins2 (24506) Ins2  (MGI:96573)   Mutation details: The transgenic construct contains cDNA of the human HBEGF (heparin-binding EGF-like growth factor) gene under the control of a 0.7Kb fragment of the rat insulin 2 promoter, and a 1.6 kb-long sequence containing an intron and the polyA signal of the rabbit beta globin gene. (J:225120)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:225120 Yang C, et al., Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets. Diabetes Metab Syndr Obes. 2015;8:387-98
All:	4 reference(s)