Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Lrp4mdig-3J
Name:	low density lipoprotein receptor-related protein 4; malformed digits 3 Jackson
MGI ID:	MGI:5688522
Gene:	Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Alliance:	Lrp4mdig-3J page

Strain of Origin:

B6.129-Reg3gtm1.1Lvh/J

Allele Type:    Spontaneous (Hypomorph) Mutation:    Single point mutation   Mutation details: A spontaneous C-to-T transition at chromosome 2 position 91,492,644 bp (GRCm38) changes amino acid 1158 from arginine to tryptophan (p.R1158W) in the third beta-propeller domain. (J:222308, J:224655) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:	97 strains or lines available

Original:	J:224655 Harris BS, et al., The malformed digits 3 Jackson mutation. MGI Direct Data Submission. 2015;
All:	2 reference(s)