Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ddr2tm2.1(cre/Esr1*)Rcow
Name:	discoidin domain receptor family, member 2; targeted mutation 2.1, Randy T Cowling
MGI ID:	MGI:5662371
Gene:	Ddr2  Location: Chr1:169799876-169938331 bp, - strand  Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
Alliance:	Ddr2tm2.1(cre/Esr1*)Rcow page

Germline Transmission:	Earliest citation of germline transmission: J:214642
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Ddr2tm2.1(cre/Esr1*)Rcow expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ddr2 (MGI:1345277)   Mutation details: Part of exon 2 was replaced with two mutated mouse estrogen receptors that sequester cre to the cytoplasm, polyadenylation sequence and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:214642)

Activity:	Tissue activity of this recombinase allele
Driver:	Ddr2 (mouse) Summary of all recombinase alleles driven by Ddr2. Alliance mouse Ddr2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddr2 Mutation:	60 strains or lines available

Original:	J:214642 Cowling RT, et al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H773-81
All:	1 reference(s)