Tg(Tcra,Tcrb)3Litt
Transgene Detail
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| Symbol: |
Tg(Tcra,Tcrb)3Litt |
| Name: |
transgene insertion 3, Dan R Littman |
| MGI ID: |
MGI:5661222 |
| Synonyms: |
1A2Tg |
| Transgene: |
Tg(Tcra,Tcrb)3Litt Location: unknown
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| Alliance: |
Tg(Tcra,Tcrb)3Litt page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Tcra,Tcrb)3Litt expresses
2 genes
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Mutation details: Clone 1A2 was derived from a screen for TCR hybridomas prepared from TH17 intestinal CD4+ T cells responding to fecal material from segmented filamentous bacteria (SFB)-monoassociated mice. The receptor recognizes SFB epitope QFSGAVPNK. CDR3 Vbeta14 (AWSQGGREEQY) and Valpha15 (ATVFMNYNQGKLI) TCR sequences associated with the clone were introduced to vectors that enable transcription under the control of the natural TCRalpha and -beta promoter/enhancer elements.
(J:212833)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:212833 Yang Y, et al., Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 2014 Jun 5;510(7503):152-6 |
| All: |
1 reference(s) |
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Analysis Tools
