Tg(Mt1-HBV)28Bri
Transgene Detail
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| Symbol: |
Tg(Mt1-HBV)28Bri |
| Name: |
transgene insertion 28, Ralph L Brinster |
| MGI ID: |
MGI:5648219 |
| Synonyms: |
MT-PSX, Tg[MT-1,HBV]Bri28, TM 23-3 |
| Transgene: |
Tg(Mt1-HBV)28Bri Location: unknown
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| Alliance: |
Tg(Mt1-HBV)28Bri page
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| Strain of Origin: |
C57BL/6 x SJL
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains the zinc-inducible mouse metallothionein I promoter sequences upstream of the hepatitis B virus HBsAg coding region. The HBsAg coding region is the 2.3 kbp BglII A fragment from the hepatitis B virus genome spanning nucleotides 2839 and 1986 (from GenBank V01460.1). This region contains the entire HBV envelope/surface antigen (HBsAg) open reading frame (pre-S1, pre-S1 and S), the region between the S and X genes, and the X gene. The HBV large envelope protein is produced only from a larger transcript emanating from the transcription start sites defined by the mouse metallothionein I promoter, but the middle and small envelope proteins are regulated by a constitutively active internal promoter located within the envelope coding region.
(J:139865)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:139865 Chisari FV, et al., A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science. 1985 Dec 6;230(4730):1157-60 |
| All: |
4 reference(s) |
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Analysis Tools
