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Gene Expression Data
Assay Details
Assay
Reference: J:34996 Vanden Heuvel GB, et al., Expression of a cut-related homeobox gene in developing and polycystic mouse kidney. Kidney Int. 1996 Aug;50(2):453-61
Assay type: RNA in situ
MGI Accession ID: MGI:5646559
Gene symbol: Cux1
Gene name: cut-like homeobox 1
Probe: Cut1 probe1
Probe preparation: Antisense labelled with P32 RNA
Visualized with: Autoradiography
Results
Specimen 1a/b: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: telencephalon Strong Regionally restricted 1a/b Most highly expressed in basal ganglia.
TS20: cerebral cortex subventricular zone Present Regionally restricted 1a/b Expression in ventricular and subventricular zones of neocortex.
TS20: cerebral cortex ventricular layer Present Regionally restricted 1a/b Expression in ventricular and subventricular zones of neocortex.
TS20: neocortex Present Regionally restricted 1a/b Expression in ventricular and subventricular zones of neocortex.
TS20: cerebellum primordium Present 1a/b
TS20: midbrain roof plate Present 1a/b
TS20: lung Weak 1a/b
TS20: metanephros Weak 1a/b

Specimen 1d/e: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: brain Present 1d/e
TS21: dorsal root ganglion Strong 1d/e
TS21: limb pre-cartilage condensation Strong 1d/e
TS21: lung Strong 1d/e
TS21: metanephros Strong 1d/e
TS21: ventricular layer Present 1d/e Authors report expression in the ventricular zone of the central nervous system.
TS21: vibrissa Present Regionally restricted 1d/e Expression in sensory whiskers (mystacial vibrissae).
TS21: liver Absent 1d/e

Specimen 2a/b: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: nephrogenic zone Strong 2a/b
TS21: metanephros Present Regionally restricted 2a/b Less expression in the juxtamedullary region.
TS21: mesonephros Present Regionally restricted 2a/b
TS21: nephric duct, mesonephric portion Present Regionally restricted 2a/b
TS21: dorsal root ganglion Strong 2a/b
TS21: cartilage Weak 2a/b
TS21: liver Absent 2a/b

Specimen 3a: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: early nephron Present Regionally restricted 3a Expression in s-shaped body.
TS20: ureteric tip Present 3a

Specimen 3b: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: primitive collecting duct Strong Regionally restricted 3b Abundant expression in branching ureteric bud.
TS21: renal vesicle Present 3b
TS21: mesenchyme of metanephros Present Regionally restricted 3b Expression in uninduced mesenchyme in nephrogenic zone.
TS21: cap mesenchyme Present 3b Expression in condensed mesenchyme.

Specimen 4a/b: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: nephrogenic zone Strong 4a/b Expression in both mesenchymal and epithelial cells compartments.
TS27: inner renal medulla Moderate 4a/b Expression in developing tubules in renal medulla and papilla.
TS27: medullary tubule Moderate 4a/b Expression in developing tubules in renal medulla and papilla.
TS27: renal cortex Ambiguous 4a/b No expression in juxtamedularry cortex except for regions corresponding to medullary rays.

Specimen 4c: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cortical renal tubule Weak 4c
TS27: maturing glomerular tuft Weak 4c

Specimen 4d: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: s-shaped body Strong 4d

Specimen 6a/b: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: urothelium of bladder Strong 6a/b Most hhighley expression in transitional cell epithelium.
TS24: detrusor muscle of bladder Present 6a/b Expression also detected in smooth muscle of bladder.
TS24: lamina propria of bladder Absent 6a/b

Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: metanephros Absent Authors state that expression was not above background.

Specimen 7a/b: postnatal day 21; Cys1cpk/Cys1cpk (more )
Structure Level Pattern Image Note
TS28: metanephros epithelium Strong Regionally restricted 7a/b In polycystic kidney, high experssion in cyst epithelium.

Specimen 7c/d: postnatal day 21 (more )
Note: May be from wild-type or heterozygous litter mate to cpk/cpk mutant embryo.
Structure Level Pattern Image Note
TS28: metanephros epithelium Ambiguous 7c/d Minimal expression in phenotypically normal kidney.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory