Dyrk1atm1.1Grc
Targeted Allele Detail
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Symbol: |
Dyrk1atm1.1Grc |
Name: |
dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1.1, Gerald R Crabtree |
MGI ID: |
MGI:5645356 |
Gene: |
Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
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Alliance: |
Dyrk1atm1.1Grc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:101977
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: LoxP-flanked neomycin resistance cassettes were introduced both 5' and 3' of the exon that encodes the kinase active site (the fifth coding exon). The 5' neomycin cassette was excised with Cre recombinase during vector construction in E. coli. Cre-mediated recombination removed the 3' floxed neo cassette, leaving the kinase active site exon flanked by loxP sites.
(J:101977)
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Original: |
J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017; |
All: |
1 reference(s) |
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