Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Col1a1tm2.1(CAG-cre/ERT2)Dgk
Name:	collagen, type I, alpha 1; targeted mutation 2.1, David Kirsch
MGI ID:	MGI:5642281
Synonyms:	Col1a1FRT-Cre-ER-T2-FRT
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm2.1(CAG-cre/ERT2)Dgk page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Col1a1tm2.1(CAG-cre/ERT2)Dgk expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: A targeting vector was designed to insert (from 5 to 3) a CAG promoter, a frt-flanked CreERT2 (Cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, and an attB/attP-flanked neomycin (neo) resistance cassette downstream of the collagen A1 (Col1a1) promoter. PhiC31-mediated recombination removed the neo cassette. (J:101977)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	3 reference(s)