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Gene Expression Data
Assay Details
Assay
Reference: J:190313 Moreno-Garcia MA, et al., The methylmalonic aciduria related genes, Mmaa, Mmab, and Mut, are broadly expressed in placental and embryonic tissues during mouse organogenesis. Mol Genet Metab. 2012 Nov;107(3):368-74
Assay type: RNA in situ
MGI Accession ID: MGI:5642216
Gene symbol: Mmaa
Gene name: methylmalonic aciduria (cobalamin deficiency) type A
Probe: Mmaa cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A,D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: labyrinthine zone Present 1A
TS17: spongiotrophoblast Present 1A , 1D
TS17: trophoblast giant cell Present 1A , 1D
Specimen 2A-F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: embryo Present Regionally restricted 2A Expression was ubiquitous in all structures along the anterior and posterior axis.
TS17: heart Present 2D , 2A
TS17: branchial arch Present 2C , 2A
TS17: central nervous system Present 2B , 2A
TS17: neural tube Present 2B , 2A
TS17: nephric duct Trace 2A , 2F , 2E
Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: blood vessel endothelium Present 3A
TS19: head mesenchyme Present 3A
Specimen 3D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: Rathke's pouch Present 3D
Specimen 3G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: heart Present 3G
Specimen 3J: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: liver Present 3J
Specimen 3M: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present 3M
TS19: blood vessel Present Regionally restricted 3M Expression was detected in intersomitic blood vessels.
Specimen 3P: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lung mesenchyme Present 3P
Specimen 4A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: head mesenchyme Present 4A
TS20: blood vessel endothelium Present 4A Expression was higher in the head blood vessel endothelium than in the head mesenchyme.
Specimen 4D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pituitary gland Absent 4D
Specimen 4G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: heart Present 4G
Specimen 4J: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lung vascular element Present 4J
TS20: lung Present Regionally restricted 4J Expression was highest in the endothelial cells of vessels and was not observed in the lung buds.
Specimen 4M: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midgut mesenchyme Present Widespread 4M
TS20: midgut Present Widespread 4M Expression was broadly expressed in the midgut mesenchyme and endoderm.
Specimen 4P: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: urogenital sinus Present 4P
TS20: hindgut Present Regionally restricted 4P Expression was in the rectum.
TS20: blood vessel endothelium Present 4P
TS20: developing vasculature of urogenital sinus Present 4P
Specimen 4S: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: liver Present 4S Expression was highest in the endothelial cells.
Specimen 4V: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: metanephros Present 4V
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory