Tg(Rho*)TTM4Rieke
Transgene Detail
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| Symbol: |
Tg(Rho*)TTM4Rieke |
| Name: |
transgene insertion TTM4, Fred Rieke |
| MGI ID: |
MGI:5641188 |
| Synonyms: |
Tg(RhoT336A/T340A/T342A) |
| Transgene: |
Tg(Rho*)TTM4Rieke Location: unknown
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| Alliance: |
Tg(Rho*)TTM4Rieke page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Tg(Rho*)TTM4Rieke expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Sag (MGI:98227) |
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Mutation details: The transgene expresses mouse Rho in which phosphorylating threonines 336, 340 and 342 have been converted to inactivating alanines. Serine-associated phosphorylation sites (S334, S338 and S343) remain functional. An A337V mutation was introduced to confer a linear epitope for mAb3A6, that allows specific recognition of transgenic versus endogenous opsin.
(J:221472)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:221472 Azevedo AW, et al., C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife. 2015;4 |
| All: |
1 reference(s) |
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Analysis Tools
