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Tg(Rho*)2PRieke
Transgene Detail
Summary
Symbol: Tg(Rho*)2PRieke
Name: transgene insertion 2P, Fred Rieke
MGI ID: MGI:5640778
Synonyms: 2P, S334/S338/CSM
Transgene: Tg(Rho*)2PRieke  Location: unknown  
Alliance: Tg(Rho*)2PRieke page
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Tg(Rho*)2PRieke expresses 1 gene
 
Mutation detailsThe transgene expresses mouse Rho carrying only the S334 and S338 phosphorylation sites. The remaining phosphorylation sites in the Rho transgene (T336, T340, T342 and S343) are inactivated via serine or threonine to alanine mutations. An A337V mutation was introduced to confer a linear epitope for mAb3A6, that allows specific recognition of transgenic versus endogenous opsin. (J:188325)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:188325 Mendez A, et al., Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron. 2000 Oct;28(1):153-64
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory