Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rapgef4tm1Yish
Name:	Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 1, Yoshihiro Ishikawa
MGI ID:	MGI:5638899
Gene:	Rapgef4  Location: Chr2:71811584-72087818 bp, + strand  Genetic Position: Chr2, 42.9 cM, cytoband C3
Alliance:	Rapgef4tm1Yish page

Germline Transmission:	Earliest citation of germline transmission: J:213804
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of exon 1 and part of intron 1 were replaced with a floxed pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of expression in hearts from homozygous mice. (J:213804)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rapgef4 Mutation:	64 strains or lines available

Original:	J:213804 Okumura S, et al., Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J Clin Invest. 2014 Jun 2;124(6):2785-801
All:	2 reference(s)