Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gsdmatm1Tshir
Name:	gasdermin A; targeted mutation 1, Toshihiko Shiroishi
MGI ID:	MGI:5638703
Synonyms:	GsdmaL, GsdmaLacZ
Gene:	Gsdma  Location: Chr11:98555177-98568534 bp, + strand  Genetic Position: Chr11, 62.34 cM
Alliance:	Gsdmatm1Tshir page

Germline Transmission:	Earliest citation of germline transmission: J:218441
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ cassette with a 5' loxP site and a polyadenylation sequence was inserted at the translation initiation site in exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Immunohistochemistry confirmed the absence of protein expression in skin and stomach at E18.5. (J:218441)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gsdma Mutation:	23 strains or lines available

Original:	J:218441 Tanaka S, et al., Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3 (Bethesda). 2013 Oct;3(10):1843-50
All:	1 reference(s)