Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nmstm1.1Ywa
Name:	neuromedin S; targeted mutation 1.1, Masashi Yanagisawa
MGI ID:	MGI:5638422
Gene:	Nms  Location: Chr1:38978230-38989357 bp, + strand  Genetic Position: Chr1, 17.31 cM
Alliance:	Nmstm1.1Ywa page

Germline Transmission:	Earliest citation of germline transmission: J:219926
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector containing an FRT-flanked PGK-NEO cassette, a DTA cassette and a Cre recombinase cassette are used to replace the start codon in exon 1 and 59 bp of signal peptide sequence at the ATG start codon. Flp-mediated recombination removed the FRT-flanked neo cassette. Immunostaining analysis of the suprachiasmatic nucleus does not detect a gene product. The investigator reports that the Cre recombinase cassette is non-functional or very minimally functional. (J:219926)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nms Mutation:	19 strains or lines available

Original:	J:219926 Lee IT, et al., Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron. 2015 Mar 4;85(5):1086-102
All:	1 reference(s)