Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Apptm3.1Tcs
Name:	amyloid beta precursor protein; targeted mutation 3.1, Takaomi C Saido
MGI ID:	MGI:5637817
Synonyms:	AppNL-G-F
Gene:	App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	Apptm3.1Tcs page

Germline Transmission:	Earliest citation of germline transmission: J:212758
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Humanized sequence) Mutation:    Insertion   Mutation details: The sequence of exon 16 was humanized and the Swedish mutations (KM670/671NL) were introduced, the Arctic (E22G) and Beyreuther/Iberian mutations (I716F) were inserted into exon 17 and a floxed neo cassette was inserted in intron 16 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:212758)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:	89 strains or lines available

Original:	J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
All:	130 reference(s)