Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Nfatc1tm1.1(cre/ERT2)Bzsh
Name:	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
MGI ID:	MGI:5637438
Synonyms:	Nfatc1-CreER
Gene:	Nfatc1  Location: Chr18:80649420-80756286 bp, - strand  Genetic Position: Chr18, 53.66 cM, cytoband E4
Alliance:	Nfatc1tm1.1(cre/ERT2)Bzsh page

Germline Transmission:	Earliest citation of germline transmission: J:212075
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Nfatc1tm1.1(cre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Nfatc1 (MGI:102469)   Mutation details: The coding sequence in exon 1 from the translation start site was replaced by an inducible cre recombinase gene (cre/ERT2). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the recombinase. Immunohistochemistry confirmed expression in the atrial and ventricular endocardium, but not sinus venosus, at E8.5 and E9.5. (J:212075)

Activity:	Tissue activity of this recombinase allele
Driver:	Nfatc1 (mouse) Summary of all recombinase alleles driven by Nfatc1. Comparative matrix view of recombinase activities Alliance mouse Nfatc1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc1 Mutation:	47 strains or lines available

Original:	J:212075 Tian X, et al., Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014 Jul 4;345(6192):90-4
All:	8 reference(s)