Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm2(tetO-GFP/RNAi:Ren)Radi
Name:	collagen, type I, alpha 1; targeted mutation 2, Ross A Dickins
MGI ID:	MGI:5636604
Synonyms:	TREtight-GFP-Ren.713
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm2(tetO-GFP/RNAi:Ren)Radi page

Germline Transmission:	Earliest citation of germline transmission: J:211775
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Knockdown, RMCE-ready) Mutation:    Insertion   Mutation details: RMCE on KH2 cells inserted a cassette that contains the tetracycline promoter and a GFP fusion with an Mir30e-based short hairpin sequence targeting Ren (Ren.713) into the 3'UTR. (J:211775)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:211775 Liu GJ, et al., Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia. Genes Dev. 2014 Jun 15;28(12):1337-50
All:	1 reference(s)