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Gene Expression Data
Assay Details
Assay
Reference: J:46409 Hirsch MR, et al., Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development. 1998 Feb;125(4):599-608
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5636468
Gene symbol: Phox2b
Gene name: paired-like homeobox 2b
Antibody: anti-Phox2b
Results
Specimen 1C: embryonic day 10.5; Ascl1tm1And/Ascl1+ (more )
Note: Section through the cervical region. Double labeled: orange - Phox2b; black - Ret (assay MGI:5636466).
Structure Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 1C Expression was detected in sympathetic neuroblasts.
Specimen 1D: embryonic day 10.5; Ascl1tm1And/Ascl1tm1And (more )
Note: Section through the cervical region. Double labeled: orange - Phox2b; black - Ret (assay MGI:5636466).
Structure Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 1D Expression was detected in sympathetic neuroblasts.
Specimen 1G: embryonic day 10.5; Ascl1tm1And/Ascl1+ (more )
Note: Section through the thoracic region.
Structure Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 1G Expression was detected in sympathetic neuroblasts.
Specimen 1H: embryonic day 10.5; Ascl1tm1And/Ascl1tm1And (more )
Note: Section through the thoracic region.
Structure Level Pattern Image Note
TS17: sympathetic nervous system Present Regionally restricted 1H Expression was detected in sympathetic neuroblasts.
Specimen 1K: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: inferior cervical ganglion Present Regionally restricted 1K Expression was detected in sympathetic neuroblasts.
Specimen 1L: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: inferior cervical ganglion Present Regionally restricted 1L The few surviving sympathoblasts are labelled in the rudimentary ganglion in the mutant.
Specimen 2A: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: parasympathetic ganglion Present 2A
TS21: sphenopalatine ganglion Present 2A
Specimen 2B: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: sphenopalatine ganglion Present 2B The immunopositive cells appeared less densely packed than in wild type.
Specimen 2G: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: otic ganglion Present 2G
TS21: parasympathetic ganglion Present 2G
Specimen 2H: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: otic ganglion Present 2H
TS21: parasympathetic ganglion Present 2H
Specimen 3A: embryonic day 16.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS24: sphenopalatine ganglion Present 3A
Specimen 3B: embryonic day 16.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS24: sphenopalatine ganglion Present 3B Only a few cells remain in the mutant atrophic sphenopalatine ganglion.
Specimen 3E: postnatal newborn; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS27: sphenopalatine ganglion Present 3E
Specimen 3F: postnatal newborn; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS27: sphenopalatine ganglion Present 3F Only a few cells remain in the mutant atrophic sphenopalatine ganglion.
Specimen 3I: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: parasympathetic ganglion Present Regionally restricted 3I Expression was detected in the ciliary ganglion.
TS21: pigmented retinal epithelium Absent 3I
Specimen 3J: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: pigmented retinal epithelium Absent 3J
Specimen 4A: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: esophagus Present Regionally restricted 4A Expression was detected in the myenteric plexus of the stomach and lower esophagus.
TS21: stomach Present Regionally restricted 4A Expression was detected in the myenteric plexus of the stomach and lower esophagus.
Specimen 4B: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: esophagus Present Regionally restricted 4B Expression was detected in the myenteric plexus of the stomach and lower esophagus.
TS21: stomach Present Regionally restricted 4B Expression was detected in the myenteric plexus of the stomach and lower esophagus.
Specimen 4E: embryonic day 13.5; Ascl1tm1And/Ascl1+ (more )
Structure Level Pattern Image Note
TS21: esophagus Present Regionally restricted 4E Expression was detected in the myenteric plexus of the upper esophagus.
Specimen 4F: embryonic day 13.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS21: esophagus Present Regionally restricted 4F Expression was detected in the myenteric plexus of the upper esophagus.
Specimen not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: esophagus Present Regionally restricted Expression was detected in the esphageal wall.
Specimen not shown: embryonic day 12.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS20: esophagus Present Regionally restricted Expression was detected in the esphageal wall.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory