Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Scn4btm1.1Geh
Name:	sodium channel, type IV, beta; targeted mutation 1.1, Gregg E Homanics
MGI ID:	MGI:5634084
Gene:	Scn4b  Location: Chr9:45049922-45065453 bp, + strand  Genetic Position: Chr9, 24.84 cM
Alliance:	Scn4btm1.1Geh page

Germline Transmission:	Earliest citation of germline transmission: J:261348
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site, followed by a FRT-flanked neomycin resistance (neo) cassette, upstream of exon 2, and a second loxP site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:261348)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scn4b Mutation:	19 strains or lines available

Original:	J:261348 Ji X, et al., The Sodium Channel beta4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons. Front Cell Neurosci. 2017;11:17
All:	1 reference(s)