Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ap1s2tm1Pschu
Name:	adaptor-related protein complex 1, sigma 2 subunit; targeted mutation 1, Peter Schu
MGI ID:	MGI:5620801
Synonyms:	sigma1B-
Gene:	Ap1s2  Location: ChrX:162692013-162716662 bp, + strand  Genetic Position: ChrX, 75.97 cM, cytoband F5
Alliance:	Ap1s2tm1Pschu page

Germline Transmission:	Earliest citation of germline transmission: J:218588
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced part of exon 3. This allele targets the sigma1B isoform. Northern-blot analysis confirmed the absence of transcript in mutant mouse embryonic fibroblasts. (J:218588)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap1s2 Mutation:	7 strains or lines available

Original:	J:218588 Glyvuk N, et al., AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 2010 Apr 21;29(8):1318-30
All:	6 reference(s)