Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc7a5tm1.1Daca
Name:	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; targeted mutation 1.1, Doreen A Cantrell
MGI ID:	MGI:5618433
Synonyms:	Slc7a5fl, Slc7a5-Flox
Gene:	Slc7a5  Location: Chr8:122607885-122634425 bp, - strand  Genetic Position: Chr8, Syntenic
Alliance:	Slc7a5tm1.1Daca page

Germline Transmission:	Earliest citation of germline transmission: J:196444
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector contains loxP sites flanking exon 1, including the initiation codon. An FRT-flanked neomycin resistance (neo) cassette fused to an internal ribosomal entry site (IRES) and a splice donor (SD) sequence, followed by a third loxP site, are placed downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo-IRES-SD cassette. (J:213820)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc7a5 Mutation:	31 strains or lines available

Original:	J:196444 Sinclair LV, et al., Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 2013 May;14(5):500-8
All:	11 reference(s)