Summary | Mutation origin | Mutation description | Recombinase activity | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm3(CAG-Cre/ERT2)Dsa
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Dieter Saur
MGI ID:	MGI:5616874
Synonyms:	FSF-R26-CAG-CreER
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm3(CAG-Cre/ERT2)Dsa page

Germline Transmission:	Earliest citation of germline transmission: J:218155
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm3(CAG-Cre/ERT2)Dsa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: A targeting vector containing a CAG promoter and a FRT-flanked transcriptional and translational stop sequence with a neomycin resistance gene 5' of the CreERT2 expression cassette was generated. (J:218155)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm3(CAG-Cre/ERT2)Dsa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7
All:	19 reference(s)