Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo
Name:	transgene insertion Y74, David R Borchelt
MGI ID:	MGI:5615836
Synonyms:	TUL-Y74
Transgene:	Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo  Location: unknown
Alliance:	Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Humanized sequence, Inducible, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Mutation details: The transgenic construct includes a Tet-responsive element (TRE) and exons 1-2 (non-coding) from the mouse prion protein upstream of a Tau-Ubiquitin-Luciferase (TUL) cDNA sequence, followed by mouse prion protein exon 3 (non-coding) and polyadenylation signal. The TUL cDNA sequence encodes a mutant human tau-P301L with C-terminal ubiquitin, followed by a luciferase gene. (J:101977, J:234694)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:234694 Fromholt S, et al., Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimers Res Ther. 2016;8:36
All:	2 reference(s)