Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(CMV-Plaur*)19Lbh
Name:	transgene insertion 19, Lawrence B Holzman
MGI ID:	MGI:5613978
Synonyms:	CMVflox-suPAR-FL
Transgene:	Tg(CMV-Plaur*)19Lbh  Location: unknown
Alliance:	Tg(CMV-Plaur*)19Lbh page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence, No functional change) Mutation:    Insertion   Tg(CMV-Plaur*)19Lbh expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Plaur (MGI:97612)   Mutation details: The construct is designed with the CMV-IE enhancer/chicken beta-actin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette (containing beta galactosidase and a polyadenylation signal), and the soluble form of the murine urokinase-type plasminogen activator receptor (Plaur) gene. The soluble form of Plaur (suPAR) encodes a 60 kDa truncated protein, lacking the glycophosphatidylinositol (GPI) anchored three domain (commonly referred to as D1, D2, D3) protein. (J:217443)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:217443 Spinale JM, et al., A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney Int. 2015 Mar;87(3):564-74
All:	1 reference(s)