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Gene Expression Data
Assay Details
Assay
Reference: J:169752 Kriegbaum MC, et al., Expression of C4.4A, a Structural uPAR Homolog, Reflects Squamous Epithelial Differentiation in the Adult Mouse and during Embryogenesis. J Histochem Cytochem. 2011 Feb;59(2):188-201
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5612964
Gene symbol: Lypd3
Gene name: Ly6/Plaur domain containing 3
Antibody: anti-C4.4A
Detection system: Secondary antibody coupled to horseradish peroxidase
Assay notes: Tissue was fixed in 4% formalin. All organs were examined in duplicate from two different mice.
Results
Specimen 1A/B: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: esophagus squamous epithelium Present Regionally restricted 1B , 1A Expression is restricted to the stratum spinosum, leaving the basal layer and stratum granulosum negative.

Specimen Table 1 - mouse: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: oral epithelium Present Expression in stratified squamous epithelium.
TS28: tongue epithelium Present Expression in stratified squamous epithelium.
TS28: esophagus squamous epithelium Present
TS28: stomach glandular region Absent
TS28: stomach squamous epithelium Present Expression in the non-glandular stomach.
TS28: duodenum Absent
TS28: jejunum Absent
TS28: ileum Absent
TS28: ascending colon Absent
TS28: sigmoid colon Absent
TS28: rectum Absent
TS28: anal canal epithelium Present Expression in stratified squamous epithelium.
TS28: ovary Absent
TS28: uterus Absent
TS28: epithelium of vagina Present Expression in stratified squamous epithelium.
TS28: testis Absent
TS28: epididymis Absent
TS28: prostate gland Absent
TS28: seminal vesicle Absent
TS28: skin Present Regionally restricted Expression in stratified squamous epithelium.
TS28: hair follicle Present Expression in stratified squamous epithelium.
TS28: bone Absent
TS28: bone marrow Absent
TS28: cornea epithelium Present Expression in stratified squamous epithelium.
TS28: pigmented retinal epithelium Present
TS28: adipose tissue Absent
TS28: brain Absent
TS28: hassall's corpuscle Present
TS28: spleen Absent
TS28: lymph node Absent
TS28: liver Absent
TS28: pancreas Absent
TS28: mammary gland Absent No expression in mammae.
TS28: metanephros Absent
TS28: bladder Absent
TS28: heart Absent
TS28: striated muscle tissue Absent
TS28: smooth muscle tissue Absent
TS28: nasal cavity epithelium Present Expression in stratified squamous epithelium.
TS28: trachea Absent
TS28: lung Absent

Specimen 2A: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: tongue epithelium Present 2A

Specimen 2B: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: esophagus squamous epithelium Present 2B Expression is present along the length of the esophagus.

Specimen 2C: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: stomach squamous epithelium Present 2C Expression in non-glandular epithelium.
TS28: stomach glandular region epithelium Absent 2C

Specimen 2D: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: stomach squamous epithelium Present 2D Expression in non-glandular epithelium.
TS28: stomach glandular region epithelium Absent 2D

Specimen 2E: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: duodenum epithelium Absent 2E No expression in columnar epithelium.

Specimen 2F: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: colon epithelium Absent 2F No expression in columnar epithelium of the sigmoid colon.

Specimen 2G: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: anal canal epithelium Present Regionally restricted 2G Expression is present at the ano-rectal junction, at the transition zone between the columnar epithelium and stratified squamous epithelium.

Specimen 2H: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: anal canal epithelium Present Regionally restricted 2H Expression is present at the ano-rectal junction, at the transition zone between the columnar epithelium and stratified squamous epithelium.

Specimen 3A: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: epithelium of vagina Present 3A Expression is present in the stratified squamous epithelium.
TS28: endometrium epithelium Absent 3A There is no expression in the columnar epithelium of the uterus.

Specimen 3C: postnatal week 12 (more )
Note: caudal vagina
Structure Level Pattern Image Note
TS28: epithelium of vagina Present 3C Expression is present in the stratified squamous epithelium.

Specimen 3E: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: epithelium of epididymis Absent 3E There is no expression in the ductal epithelium.

Specimen 3G: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: hassall's corpuscle Present 3G

Specimen 4A: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: mammary gland epithelium Present 4A Expression is present in the keratinocytes in the epidermis of the mammae.

Specimen 4B: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: hair outer root sheath Present Widespread 4B Expression in present in the most distal part all the way to the orifice of sebaceous glands.

Specimen 4C/D/E: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: cornea epithelium Present 4D , 4C Expression is present in the squamous epithelium.
TS28: pigmented retinal epithelium Present 4E , 4C

Specimen 4F: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: lung epithelium Absent 4F

Specimen 4G: postnatal week 12 (more )
Structure Level Pattern Image Note
TS28: urothelium of bladder Absent 4G

Specimen Table 2 - E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: nose Absent No expression in the nasal cavity.
TS15: oral region Absent No expression in the tongue.
TS15: esophageal region Absent No expression in the esophagus.
TS15: foregut Absent No expression in the non-glandular stomach.
TS15: hindgut Absent No expression in the anus.
TS15: surface ectoderm Absent No expression in back skin.
TS15: limb ectoderm Absent No expression in paw skin.
TS15: embryo ectoderm Absent No expression in vibrissae follicles.

Specimen Table 2 - E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: nasal cavity epithelium Strong
TS21: tongue Absent
TS21: esophagus Absent
TS21: stomach proventricular region Absent No expression in non-glandular stomach.
TS21: anal region Absent
TS21: back skin Absent
TS21: autopod skin Weak Regionally restricted Expression in outer cell layers of the paws.
TS21: vibrissa follicle Absent

Specimen Table 2 - E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: nasal cavity epithelium Strong
TS22: tongue epithelium Weak
TS22: esophagus Absent
TS22: stomach proventricular region Absent No expression in non-glandular stomach.
TS22: anal canal epithelium Weak Weak expression in the squamous epithelium of the anus.
TS22: back skin Weak Regionally restricted Weak expression in the stratum spinosum.
TS22: autopod skin Weak
TS22: vibrissa follicle Moderate

Specimen Table 2 - E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: nasal cavity epithelium Strong
TS23: tongue epithelium Moderate
TS23: esophagus epithelium Weak
TS23: stomach proventricular region epithelium Weak Weak expression in the squamous epithelium of the non-glandular stomach.
TS23: anal canal epithelium Strong Strong expression in the squamous epithelium of the anus.
TS23: back skin Strong
TS23: autopod skin Strong
TS23: vibrissa follicle Strong

Specimen Table 2 - E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: nasal cavity epithelium Strong
TS24: tongue epithelium Strong
TS24: esophagus epithelium Weak
TS24: stomach proventricular region epithelium Moderate Moderate expression in the squamous epithelium of non-glandular stomach.
TS24: anal canal epithelium Strong Strong expression in the squamous epithelium of the anus.
TS24: back skin Strong Regionally restricted This expression is not in the stratum corneum and underlying stratum granulosum.
TS24: autopod skin Strong
TS24: vibrissa follicle Strong

Specimen Table 2 - E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: nasal cavity epithelium Strong
TS25: tongue epithelium Strong
TS25: esophagus epithelium Moderate
TS25: stomach proventricular region epithelium Strong Strong expression in the squamous epithelium of non-glandular stomach.
TS25: anal canal epithelium Strong Strong expression in the squamous epithelium of the anus.
TS25: back skin Strong
TS25: autopod skin Strong
TS25: vibrissa follicle Strong

Specimen Table 2 - E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: nasal cavity epithelium Strong
TS26: tongue epithelium Strong
TS26: stomach proventricular region epithelium Strong Strong expression in the squamous epithelium of non-glandular stomach.
TS26: anal canal epithelium Strong Strong expression in the squamous epithelium of the anus.
TS26: back skin Strong
TS26: autopod skin Strong
TS26: vibrissa follicle Strong

Specimen Table 2 - Newborn: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: tongue epithelium Strong
TS27: stomach squamous epithelium Strong Strong expression in the squamous epithelium of non-glandular stomach.
TS27: anal canal epithelium Strong Strong expression in the squamous epithelium of the anus.
TS27: back skin Strong
TS27: autopod skin Strong
TS27: vibrissa follicle Strong

Specimen not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: embryo Absent

Specimen 5A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: nasal cavity epithelium Present 5A Expression present in squamous epithelium.

Specimen 5B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: nasal cavity epithelium Present 5B

Specimen 5C: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: nasal cavity epithelium Present 5C

Specimen 5D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: back skin Absent 5D

Specimen 5E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: back skin Present 5E Expression in the approaching stratum spinosum.

Specimen 5F: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: back skin Present Regionally restricted 5F Expression present in a pronounced membrane-bound appearance.

Specimen 5G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: vibrissa follicle Absent 5G

Specimen 5H: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Present 5H

Specimen 5I: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: vibrissa follicle Present 5I

Specimen 5J: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: esophagus epithelium Absent 5J

Specimen 5K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: esophagus epithelium Absent 5K

Specimen 5L: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: esophagus epithelium Weak Regionally restricted 5L Expression is present in the suprabasal layer of the squamous epithelium.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory