Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atg3tm1Kmts
Name:	autophagy related 3; targeted mutation 1, Masaaki Komatsu
MGI ID:	MGI:5609520
Gene:	Atg3  Location: Chr16:44979192-45008901 bp, + strand  Genetic Position: Chr16, 29.45 cM, cytoband B5
Alliance:	Atg3tm1Kmts page

Germline Transmission:	Earliest citation of germline transmission: J:215884
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 10, which codes the active site cysteine. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:215884)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atg3 Mutation:	19 strains or lines available

Original:	J:215884 Sou YS, et al., The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008 Nov;19(11):4762-75
All:	5 reference(s)