Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2.2Ksvo
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2.2, Keral Svoboda
MGI ID:	MGI:5605725
Synonyms:	R26 LSL-CAG-LSL-ReaChR-mCit, Rosa26 CAG-LSL-ReaChR-mCit
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2.2Ksvo page

Germline Transmission:	Earliest citation of germline transmission: J:217788
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: A CAG promoter (cytomegalovirus (CMV) enhancer fused to the chicken beta-actin promoter), FRT-flanked stop cassette, loxP-flanked stop cassette, ReaChR red-shifted channelrhodopsin, fluorescent reporter mCitrine, woodchuck hepatitis post-transcriptional regulatory element (WPRE), poly A (pA) tail, and AttB/AttP-flanked neomycin resistance cassette were introduced to intron 1 of the Gt(ROSA)26Sor gene. PhiC31o-mediated recombination removed the neomycin cassette. Flp-mediated recombination removed the FRT-flanked stop cassette. (J:217788)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	944 strains or lines available

Original:	J:217788 Hooks BM, et al., Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci. 2015 Mar 11;35(10):4418-26
All:	12 reference(s)