Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esr1tm2.1(cre)And
Name:	estrogen receptor 1 (alpha); targeted mutation 2.1, David J Anderson
MGI ID:	MGI:5605085
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm2.1(cre)And page

Germline Transmission:	Earliest citation of germline transmission: J:207677
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (RMCE-ready, Recombinase) Mutation:    Insertion   Esr1tm2.1(cre)And expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Esr1 (MGI:1352467)   Mutation details: The targeting vector was designed to insert an attP site, a 2A oligopeptide (mediates ribosomal skipping), the Cre recombinase gene, a FRT-flanked PGKneo-polyA cassette, and an attP site within the 3' UTR of the gene. Flpe-mediated recombination removed the neo cassette. (J:207677)

Activity:	Tissue activity of this recombinase allele
Driver:	Esr1 (mouse) Summary of all recombinase alleles driven by Esr1. Comparative matrix view of recombinase activities Alliance mouse Esr1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:207677 Lee H, et al., Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus. Nature. 2014 May 29;509(7502):627-32
All:	11 reference(s)