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Gene Expression Data
Assay Details
Assay
Reference: J:211539 Chen Y, et al., Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res. 2013 Jun;28(6):1412-21
Assay type: RNA in situ
MGI Accession ID: MGI:5603154
Gene symbol: Col10a1
Gene name: collagen, type X, alpha 1
Probe: Col10a1 probe8
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6C: embryonic day 14.5; Snai1tm2Grid/Snai1tm2Grid (more )
Note: littermate controls carry the floxed allele
Structure Level Pattern Image Note
TS22: femur cartilage condensation Present Regionally restricted 6C Expression is present in hypertrophic chondrocytes in the growth plate.
Specimen 6D: embryonic day 14.5; Snai1tm1Grid/Snai1tm1Grid, Snai2tm1Grid/Snai2tm1Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: femur cartilage condensation Weak Regionally restricted 6D Due to a delay in expression in the double mutants, expression levels are reduced in the double mutants relative to controls. This indicates a delay in chondrocyte prehypertrophy and hypertrophy.
Specimen 6I: embryonic day 16.5; Snai1tm2Grid/Snai1tm2Grid (more )
Note: littermate controls carry the floxed allele
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 6I Expression is present in hypertrophic chondrocytes in the growth plate.
Specimen 6J: embryonic day 16.5; Snai1tm1Grid/Snai1tm1Grid, Snai2tm1Grid/Snai2tm1Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: femur Present Regionally restricted 6J Expression levels in the double mutant have recovered from their earlier delay in expression. In addition, expression has expanded into the trabecular bone region.
Specimen S5C: embryonic day 18.0; Snai1tm2Grid/Snai1tm2Grid (more )
Note: littermate controls carry the floxed allele
Structure Level Pattern Image Note
TS26: femur Present S5C
Specimen S5D: embryonic day 18.0; Snai1tm1Grid/Snai1tm1Grid, Snai2tm1Grid/Snai2tm1Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: femur Present S5D The expression pattern in the double mutant is unaltered from that seen in controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory