Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akap6tm1.1Mskf
Name:	A kinase anchor protein 6; targeted mutation 1.1, Michael S Kapiloff
MGI ID:	MGI:5588705
Synonyms:	mAKAPfl
Gene:	Akap6  Location: Chr12:52746166-53202382 bp, + strand  Genetic Position: Chr12, 22.18 cM
Alliance:	Akap6tm1.1Mskf page

Germline Transmission:	Earliest citation of germline transmission: J:214288
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector contains a FRT-flanked neomycin cassette followed by a loxP site upstream exon 9 and loxP downstream of exon 9. Flpe mediated recombination removed the FRT-flanked neo cassette leaving exon 9 floxed. (J:214288)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap6 Mutation:	113 strains or lines available

Original:	J:214288 Kritzer MD, et al., The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014 Jul;7(4):663-72
All:	1 reference(s)