Tg(MECP2*R111G/EGFP)1Hzo
Transgene Detail
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| Symbol: |
Tg(MECP2*R111G/EGFP)1Hzo |
| Name: |
transgene insertion 1, Huda Y Zoghbi |
| MGI ID: |
MGI:5588460 |
| Synonyms: |
MECP2R111G-EGFPTg, R111G Tg |
| Transgene: |
Tg(MECP2*R111G/EGFP)1Hzo Location: unknown
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| Alliance: |
Tg(MECP2*R111G/EGFP)1Hzo page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(MECP2*R111G/EGFP)1Hzo expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MECP2 (4204) |
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Mutation details: A human PAC (PAC671D9) containing only the MECP2 locus and regulatory elements was modified to introduce a R111G (AGG to GGG) missense mutation in the methyl-CpG binding domain (MPD) of exon 3 and a C-terminal GFP tag. Expression of the transgene parallels that of endogenous MECP2 in the brain.
(J:214143)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:214143 Heckman LD, et al., Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. Elife. 2014;3 |
| All: |
1 reference(s) |
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Analysis Tools
