Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(MECP2*R111G/EGFP)1Hzo
Name:	transgene insertion 1, Huda Y Zoghbi
MGI ID:	MGI:5588460
Synonyms:	MECP2R111G-EGFPTg, R111G Tg
Transgene:	Tg(MECP2*R111G/EGFP)1Hzo  Location: unknown
Alliance:	Tg(MECP2*R111G/EGFP)1Hzo page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(MECP2*R111G/EGFP)1Hzo expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MECP2 (4204) Mecp2  (MGI:99918)   Mutation details: A human PAC (PAC671D9) containing only the MECP2 locus and regulatory elements was modified to introduce a R111G (AGG to GGG) missense mutation in the methyl-CpG binding domain (MPD) of exon 3 and a C-terminal GFP tag. Expression of the transgene parallels that of endogenous MECP2 in the brain. (J:214143)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:214143 Heckman LD, et al., Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. Elife. 2014;3
All:	1 reference(s)