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Gene Expression Data
Assay Details
Assay
Reference: J:173463 Bejarano-Escobar R, et al., Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and D. Dev Dyn. 2011 Jul;240(7):1841-55
Assay type: RNA in situ
MGI Accession ID: MGI:5588136
Gene symbol: Ctsd
Gene name: cathepsin D
Probe: mCatD cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: optic cup Present Single cells Expression is in a few large rounded cells dispersed throughout the neural retina.

Specimen 1A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: intraretinal space Present Single cells 1A
TS18: lens vesicle Present Single cells 1A
TS18: pigmented retinal epithelium Present Single cells 1A
TS18: retina Present Single cells 1A Expression is in the central retina dorsally to the optic stalk.
TS18: eye Present Single cells 1A Expression is in the mesenchyme between the cornea and the lens.
TS18: diencephalon Present Single cells 1A
TS18: neural tube ventricular layer Present Single cells 1A

Specimen 1B: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: intraretinal space Present Single cells 1B
TS18: lens vesicle Present Single cells 1B
TS18: pigmented retinal epithelium Present Single cells 1B
TS18: retina Present Single cells 1B Expression is in the central retina dorsally to the optic stalk.
TS18: eye Present Single cells 1B Expression is in the mesenchyme between the cornea and the lens.
TS18: head mesenchyme Present Regionally restricted 1B Expression is in the mesenchymal tissue around the eye.

Specimen 2A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pigmented retinal epithelium Present 2A
TS20: retina Present Single cells 2A Expression is at the posterior pole.

Specimen 2H: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: pigmented retinal epithelium Strong 2H
TS22: hyaloid cavity Present Single cells 2H
TS22: lens anterior epithelium Present Single cells 2H
TS22: retina Present Single cells 2H
TS22: lens Present Single cells 2H Within the lens vesicle cavity.

Specimen 2I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: pigmented retinal epithelium Strong 2I
TS22: retina Present Single cells 2I , 2J Labeled cells in the fundus surround the optic nerve head.

Specimen 3A: postnatal day 0 (more )
Note: B is a higher magnification of A.
Structure Level Pattern Image Note
TS27: hyaloid cavity Present 3A , 3B
TS27: pigmented retinal epithelium Present 3A , 3B
TS27: retina ganglion cell layer Present 3A , 3B

Specimen 3E: postnatal day 8 (more )
Note: F is a higher magnification of E.
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present 3F , 3E
TS28: retina inner nuclear layer Present 3F , 3E
TS28: sclera Present 3F , 3E
TS28: retina outer plexiform layer Absent 3F , 3E

Specimen 3M: postnatal day 15 (more )
Note: N is a higher magnification of M.
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present 3M , 3N
TS28: retina outer nuclear layer Present 3M , 3N

Specimen 3Q: postnatal day 20 (more )
Note: R is a higher magnification of Q.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Trace 3Q , 3R
TS28: pigmented retinal epithelium Present 3Q

Specimen 4K: embryonic day 12.0 (more )
Note: Double labeled with tomato lectin (green).
Structure Level Pattern Image Note
TS20: retina Present Single cells 4K , 4M
TS20: pigmented retinal epithelium Present 4M , 4K

Specimen 5B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: optic stalk Present Single cells 5B Expression is in the ventral region.
TS19: pigmented retinal epithelium Present 5B

Specimen 5D: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: optic stalk Present Single cells 5D Expression is in the ventral region.
TS20: pigmented retinal epithelium Present 5D

Specimen 5F: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: optic stalk Present Single cells 5F Labeled cells almost disappeared at this age.
TS22: pigmented retinal epithelium Present 5F

Specimen 6D: postnatal day 6 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present Single cells 6D

Specimen 6E: postnatal day 6 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present Single cells 6E

Specimen 6H: postnatal day 20 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present Single cells 6H

Specimen 7C: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: optic chiasma Present Single cells 7C

Specimen 7G: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: optic chiasma Present Single cells 7G

Specimen 7H: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: optic chiasma Present Single cells 7H

Specimen 7J: postnatal day 6 (more )
Structure Level Pattern Image Note
TS28: optic chiasma Present Single cells 7J

Specimen 7K: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: optic chiasma Present Spotted 7K


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory